A Phase 2 Study of Leronlimab in Combination With TAS-102 + Bevacizumab in Previously Treated Participants With mCRC

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

June 16, 2025

Primary Completion Date

January 31, 2028

Study Completion Date

March 31, 2028

Conditions
Metastatic Colorectal Cancer (mCRC)
Interventions
DRUG

350 mg leronlimab

Leronlimab (PRO) 140 is a humanized IgG4, monoclonal antibody (mAb) to the C-C chemokine receptor type 5 (CCR5)

DRUG

700 mg leronlimab

Leronlimab (PRO) 140 is a humanized IgG4, monoclonal antibody (mAb) to the C-C chemokine receptor type 5 (CCR5)

Trial Locations (6)

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

40241

RECRUITING

Norton Cancer Institute, Brownsboro Hospital Campus, Louisville

68198

RECRUITING

University of Nebraska Medical Center, Omaha

92618

RECRUITING

City of Hope Orange County Lennar Foundation Cancer Center, Irvine

94115

ACTIVE_NOT_RECRUITING

Pacific Hematology Oncology Associates, San Francisco

99208

RECRUITING

Summit Cancer Center, Spokane

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Syneos Health

OTHER

lead

CytoDyn, Inc.

INDUSTRY