UF-KURE-BCMA CAR-T Cells in Patients With Relapsed or Refractory Multiple Myeloma

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

12

Participants

Timeline

Start Date

September 30, 2025

Primary Completion Date

December 11, 2026

Study Completion Date

September 30, 2028

Conditions
Multiple MyelomaMultiple Myeloma in RelapseMultiple Myeloma, Refractory
Interventions
BIOLOGICAL

UF-KURE-BCMA CAR T-cells

"Experimental anti-BCMA CAR T-cells manufactured with a proprietary ultrafast process. Patients will receive a single dose of CAR T-cells at one of three potential doses:~* Dose -1: 3x10\^6 cells~* Dose 1: 10x10\^6 cells~* Dose 2: 15x10\^6 cells"

DRUG

Cyclophosphamide

Patients will receive 3 days of intravenous (IV) cyclophosphamide 500 mg/m\^2 days -5 to -3 or -4 to -2 where day 0 is the day of CAR T-cell infusion.

DRUG

Fludarabine

Patients will receive 3 days of IV fludarabine 30 mg/m2 days -5 to -3 or -4 to -2 where day 0 is the day of CAR T-cell infusion.

Trial Locations (1)

44106

University Hospitals Cleveland Medical Center Seidman Cancer Center, Cleveland

All Listed Sponsors
lead

David Wald

OTHER