Tazemetostat Plus CHOP in 1L T-cell Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

December 24, 2024

Primary Completion Date

October 1, 2027

Study Completion Date

October 1, 2032

Conditions
LymphomaPeripheral T Cell LymphomaAngioimmunoblastic T-cell LymphomaEnteropathy-Associated T-Cell LymphomaMonomorphic Epitheliotropic Intestinal T-Cell Lymphoma
Interventions
DRUG

Tazemetostat

EZH2 inhibitor, 200 mg tablet, taken orally per protocol.

DRUG

Doxorubicin

Anthracycline antibiotic, 10, 20, 50, 100, and 200 mg vials, via intravenous (into the vein) infusion per institutional standard of care.

DRUG

Vincristine

Vinca Alkaloid, 1, 2, and 5mL vials, via intravenous (into the vein) infusion per institutional standard of care.

DRUG

Prednisone

Corticosteroid, 1, 2.5, 5, 10, 20, 25, and 50 mg tablets, taken orally per institutional standard of care.

DRUG

Cytoxan

Alkylating agent, 100mg, 200 mg, and 500mg vials, and 1 and 2 gram vials, via intravenous (into the vein) infusion per institutional standard of care.

DRUG

Carmustine

Alkylating agent, 100 mg single dose vials, via intravenous (into the vein) infusion per institutional standard of care.

DRUG

Etoposide

Topoisomerase II inhibitor, 100mg single dose vial, via intravenous (into the vein) infusion per institutional standard of care.

DRUG

Cytarabine

Antineoplastic, 20mg single dose vial, via intravenous, intrathecal, or subcutaneous injection per institutional standard of care

DRUG

Melphalan

Alkylating agent, 90 mg multi-dose vial, via parenteral infusion per institutional standard of care.

Trial Locations (3)

02115

RECRUITING

Dana-Farber Cancer Institute, Boston

02215

NOT_YET_RECRUITING

Beth Israel Deaconess Medical Center, Boston

NOT_YET_RECRUITING

Brigham and Women's Hospital, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Ipsen

INDUSTRY

lead

Eric Jacobsen, MD

OTHER

NCT06692452 - Tazemetostat Plus CHOP in 1L T-cell Lymphoma | Biotech Hunter | Biotech Hunter