Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

PHASE3RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

March 28, 2025

Primary Completion Date

April 15, 2027

Study Completion Date

July 15, 2027

Conditions
Exocrine Pancreatic Insufficiency (EPI)Pancreatitis
Interventions
DEVICE

RELiZORB

RELiZORB (immobilized lipase) is a therapeutic device designed to enhance fat absorption in patients receiving enteral tube feedings. It works by hydrolyzing fats found in enteral formulas. RELiZORB is a single-use cartridge that connects in-line with enteral feeding sets. It contains lipase covalently bound to small polymer beads, forming a complex called iLipase, which remains within the cartridge. As the enteral formula passes through the cartridge, its fat content is hydrolyzed upon contact with iLipase. This process is especially beneficial for the absorption of long-chain polyunsaturated fatty acids, which require hydrolysis by pancreatic lipase for proper intestinal absorption. RELiZORB is compatible with a wide variety of commercially available enteral formulas.

Trial Locations (1)

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
collaborator

Alcresta Therapeutics, Inc.

INDUSTRY

lead

Massachusetts General Hospital

OTHER