Photobiomodulation and Tooth Analgesia

NARecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

July 7, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

June 30, 2027

Conditions
Dental AnaesthesiaDental PainDental Analgesia
Interventions
DEVICE

Photobiomodulation

Photomodulation (PBM) is a promising non-tissue penetrating (i.e. minimally invasive) approach for achieving tooth and soft tissue anesthesia/analgesia in dental patients. A patent pending near-infrared laser technology that aims to provide dental analgesia will be used for PBM. This intra-oral PBM device comes with a tip comprising of a series of photonic emitters with specific wavelengths that can go through the tooth structure and bone, blocking the nerve conduction like local anesthetics. Research has shown that one burst of light application (for about 20 second) can provide up to 15-20 minutes of pain relief. Based on existing research PBM does not present a serious risk to health, safety, or welfare of a subject.

DRUG

Topical Benzocaine

Topical Benzocaine at injection site to reduce discomfort of local infiltration

DRUG

Local Anesthesia

Local infiltration using local anesthetics with epinephrine

Trial Locations (1)

21201

RECRUITING

University of Maryland School of Dentistry, Pediatric Clinics, Baltimore

All Listed Sponsors
lead

University of Maryland, Baltimore

OTHER

NCT06691269 - Photobiomodulation and Tooth Analgesia | Biotech Hunter | Biotech Hunter