Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG

PHASE2CompletedINTERVENTIONAL
Enrollment

370

Participants

Timeline

Start Date

October 4, 2024

Primary Completion Date

November 1, 2024

Study Completion Date

November 1, 2024

Conditions
Cutaneous Ulcer DiseaseSkin Sores
Interventions
OTHER

Ficus septica exudate (antiseptic plant exudates)

F. septica sap contains the antibacterial alkaloid ficuseptine which exhibits activivity agaisnt S. pyogenes and H. ducreyi, two pàthogens associated with cutaneous ulcer disease in Papau New Guinea. The sap has been tested using the Ames test for mutagenesis, and found to be non-mutagenic; testing was carried out by toxicology service provider Gentronix, UK (results available separately on request).

OTHER

Pterocarpus indicus exudate

P. indicus sap exhibits antibacterial activivity agaisnt S. pyogenes, a pàthogen associated with cutaneous ulcer disease in Papau New Guinea. The sap has been tested using the Ames test for mutagenesis, and found to be non-mutagenic; testing was carried out by toxicology service provider Gentronix, UK (results available separately on request).

OTHER

Curcuma longa aqueous extract

C. longa is a culinary herb that contains the antibatieral compound curcumin. Curcumin exhibits antibacterial activity agasint S. pyogenes and has profound effects on bacterial biofilms. This intervention uses a mulch of the rhizome that has been sqeeezed to produce a curcumin containing aqueous fluid.

DRUG

Savlon antiseptic cream (cetrimide with chlorhexidine digluconate)

Common over the counter antiseptic cream

Trial Locations (1)

Unknown

Vunapope Hospital, Kokopo

All Listed Sponsors
collaborator

The Royal Botanic Gardens, Kew

UNKNOWN

lead

Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia

OTHER

NCT06690814 - Ulcer Plants: Highly Accessible Plant Antiseptics for Use in Remote Areas of PNG | Biotech Hunter | Biotech Hunter