A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

March 11, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

May 31, 2028

Conditions
NeoplasmsCarcinoma, HepatocellularCarcinoma, Non-Small-Cell LungLiver Neoplasms
Interventions
DRUG

AST-201

AST-201 is administered intravenously on Days 1, 8, and 15 of each 28-day cycle, followed by a one-week rest period. Dosing is repeated until DLT or disease progression is occurred.

Trial Locations (4)

10408

RECRUITING

National Cancer Center, Korea, Gyeonggi-do

13609

RECRUITING

CHA Bundang Medical Center, Seongnam

03722

RECRUITING

Severance Hospital, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

Sponsors
All Listed Sponsors
collaborator

CHA University

OTHER

collaborator

National Cancer Center, Korea

OTHER_GOV

collaborator

Samsung Medical Center

OTHER

collaborator

Severance Hospital

OTHER

lead

Aptamer Sciences, Inc.

INDUSTRY

NCT06687941 - A Study to Evaluate the Tolerability, Safety, and PK of AST-201 in Patients With GPC3-positive Advanced Solid Tumors | Biotech Hunter | Biotech Hunter