NCT06686745 - Study of SIM0508 Alone and in Combination in Patients With Advanced Solid Tumors | Biotech Hunter

Enrollment

130

Participants

Timeline

Start Date

December 6, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

December 30, 2028

Conditions

Advanced Solid Tumors

Interventions

DRUG

SIM0508 Tablets

Every 28 days is one cycle. Multiple dose levels of SIM0508 will be explored in dose escalation, and determine the maximum tolerated dose.

DRUG

SIM0508 in combination with olaparib

Every 28 days is one cycle.Multiple dose levels of SIM0508 and olaparib will be explored in dose escalation, and determine the maximum tolerated dose.

DRUG

SIM0508 in combination with olaparib

Every 28 days is one cycle.Patients will be administered a potential recommended dose of SIM0508 combination with olaparib established from SIM0508 combination dose escalation.

Trial Locations (2)

Unknown

RECRUITING

Fudan University Shanghai Cancer Center, Shanghai

RECRUITING

Chongqing Cancer Hospital, Chongqing