Improving Mobility After Revascularization in Peripheral Artery Disease

PHASE3RecruitingINTERVENTIONAL
Enrollment

386

Participants

Timeline

Start Date

August 4, 2025

Primary Completion Date

February 1, 2032

Study Completion Date

August 1, 2032

Conditions
Peripheral Artery DiseaseIntermittent ClaudicationPeripheral Vascular DiseaseMobility LimitationRevascularization
Interventions
BEHAVIORAL

Home Based Exercise

This is a six month intervention where participants will walk at home for exercise with guidance from a study coach. They will attend two to four weekly meetings with the coach at the clinical site in the first 4 weeks following randomization, followed by once weekly telephone coaching calls for the remainder of the six-month intervention

DRUG

Nitrate Rich Beetroot Juice

Participants will drink one shot of nitrate rich beet-root juice twice daily for six months.

BEHAVIORAL

Attention Control

"Participants will be asked to participate in weekly meetings with the coach in the attention control group for weeks 1-26. A staff member will present a topic from the National Institute on Aging age pages relevant to health, such as cancer screening or blood pressure treatment. Calls will last approximately 5-15 minutes and will focus on educational topics such as diabetes, healthy eating, and Medicare Part D."

DRUG

Placebo Beetroot Juice Without Nitrate

Participants will drink one shot of placebo beetroot without nitrate juice twice daily for six months.

Trial Locations (7)

15213

NOT_YET_RECRUITING

University of Pittsburgh, Pittsburgh

30307

NOT_YET_RECRUITING

Emory University School of Medicine, Atlanta

60611

RECRUITING

Northwestern University Feinberg School of Medicine, Chicago

60637

RECRUITING

University of Chicago, Chicago

85724

NOT_YET_RECRUITING

University of Arizona, Tucson

90242

RECRUITING

Rancho Research Institute, Downey

03766

NOT_YET_RECRUITING

Dartmouth Hitchcock Medical Center, Lebanon

All Listed Sponsors
collaborator

Rancho Research Institute

UNKNOWN

collaborator

University of Chicago

OTHER

collaborator

Wake Forest University

OTHER

collaborator

University of Pittsburgh Medical Center

OTHER

collaborator

Emory University

OTHER

collaborator

University of Arizona

OTHER

collaborator

Dartmouth-Hitchcock Medical Center

OTHER

lead

Northwestern University

OTHER