Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressive Antiretroviral Therapy

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

April 1, 2025

Primary Completion Date

October 13, 2026

Study Completion Date

August 13, 2027

Conditions
HIV-1
Interventions
BIOLOGICAL

CH505 TF chTrimer

Stabilized CH505 TF chTrimer, 300 mcg

BIOLOGICAL

3M-052-AF

3 mcg

BIOLOGICAL

Aluminum Hydroxide Suspension

500 mcg

OTHER

Sodium Chloride for Injection

Sodium chloride for injection, 0.9% USP volume-matched placebo injection.

Trial Locations (25)

10010

RECRUITING

Weill Cornell Chelsea CRS, New York

10032

NOT_YET_RECRUITING

Columbia Physicians & Surgeons (P&S) CRS, New York

10065

NOT_YET_RECRUITING

Weill Cornell Uptown CRS, New York

14642

NOT_YET_RECRUITING

University of Rochester Adult HIV Therapeutic Strategies Network CRS, Rochester

15213

NOT_YET_RECRUITING

University of Pittsburgh CRS, Pittsburgh

19104

RECRUITING

Penn Therapeutics CRS, Philadelphia

21287

NOT_YET_RECRUITING

Johns Hopkins University CRS, Baltimore

37204

NOT_YET_RECRUITING

Vanderbilt Therapeutics (VT) CRS, Nashville

43210

NOT_YET_RECRUITING

Ohio State University CRS, Columbus

44106

NOT_YET_RECRUITING

Case CRS, Cleveland

60611

NOT_YET_RECRUITING

Northwestern University CRS, Chicago

77030

NOT_YET_RECRUITING

Houston Advancing Research Team CRS, Houston

80045

RECRUITING

University of Colorado Hospital CRS, Aurora

90035

NOT_YET_RECRUITING

University of California, Los Angeles CARE Center CRS, Los Angeles

92103

NOT_YET_RECRUITING

UCSD Antiviral Research Center CRS, San Diego

94110

NOT_YET_RECRUITING

University of California, San Francisco HIV/AIDS CRS, San Francisco

98104

NOT_YET_RECRUITING

University of Washington Positive Research CRS, Seattle

90502-2052

NOT_YET_RECRUITING

Harbor University of California Los Angeles Center CRS, Torrance

30308-2012

NOT_YET_RECRUITING

The Ponce de Leon Center CRS, Atlanta

02114

RECRUITING

Massachusetts General Hospital CRS (MGH CRS), Boston

63110-1010

NOT_YET_RECRUITING

Washington University Therapeutics (WT) CRS, St Louis

07103

NOT_YET_RECRUITING

New Jersey Medical School Clinical Research Center CRS, Newark

27599-7215

NOT_YET_RECRUITING

Chapel Hill CRS, Chapel Hill

27401-1020

NOT_YET_RECRUITING

Greensboro CRS, Greensboro

45267-0405

RECRUITING

Cincinnati CRS, Cincinnati

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Duke University

OTHER

collaborator

Access to Advanced Health Institute (AAHI)

OTHER

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

NCT06680479 - Safety and Immunogenicity of Stabilized CH505 TF chTrimer Vaccination in Adults Living With HIV-1 on Suppressive Antiretroviral Therapy | Biotech Hunter | Biotech Hunter