Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

PHASE3RecruitingINTERVENTIONAL
Enrollment

316

Participants

Timeline

Start Date

June 13, 2025

Primary Completion Date

June 30, 2027

Study Completion Date

June 30, 2029

Conditions
Post-ligation Cardiac Syndrome
Interventions
DRUG

Milrinone infusion

An intravenous (iv) infusion of milrinone will be administered at an initial dose of 0.33 mcg/kg/min and accompanied by an iv bolus of 10 mL/kg of 0.9% NaCl (administered over 60 minutes).

DRUG

Placebo infusion

An iv infusion of placebo (0.9% saline) of equivalent volume will be administered. The infusion will be accompanied by an iv bolus of 10 mL/kg of 0.9% NaCl (administered over 60 minutes) to ensure blinding is maintained.

Trial Locations (19)

19104

NOT_YET_RECRUITING

University of Pennsylvania, Philadelphia

27705

NOT_YET_RECRUITING

Duke University, Durham

30322

NOT_YET_RECRUITING

Emory University, Atlanta

35249

NOT_YET_RECRUITING

University of Alabama - Birmingham, Birmingham

38103

NOT_YET_RECRUITING

Le Bonheur Children's Hospital, Memphis

39216

NOT_YET_RECRUITING

University of Mississippi Medical Center, Jackson

44106

NOT_YET_RECRUITING

Case Western Reserve University, Cleveland

45229

NOT_YET_RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

52242

NOT_YET_RECRUITING

University of Iowa, Iowa City

60611

RECRUITING

Northwestern Lurie Children's Hospital of Chicago, Chicago

73104

NOT_YET_RECRUITING

University of Oklahoma Health Sciences, Oklahoma City

75390

NOT_YET_RECRUITING

University of Texas Southwestern, Dallas

77030

NOT_YET_RECRUITING

University of Texas at Houston, Houston

84108

NOT_YET_RECRUITING

University of Utah, Salt Lake City

87131

NOT_YET_RECRUITING

University of New Mexico, Albuquerque

92123

NOT_YET_RECRUITING

Sharp Mary Birch Hospital for Women & Newborns, San Diego

92868

NOT_YET_RECRUITING

Children's Hospital of Orange County, Orange

94304

NOT_YET_RECRUITING

Stanford University, Palo Alto

02115

NOT_YET_RECRUITING

Boston Children's Hospital, Boston

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

NICHD Neonatal Research Network

NETWORK