A Clinical Trial to Investigate the Clinical Drug-Drug Interaction of Divarasib With Probe Substrates of P-Glycoprotein and Breast Cancer Resistance Protein in Healthy Participants

PHASE1CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

November 6, 2024

Primary Completion Date

December 30, 2024

Study Completion Date

December 30, 2024

Conditions
Healthy Participants
Interventions
DRUG

Digoxin

Digoxin will be administered together with Rosuvastatin as a drug cocktail as specified for the respective period

DRUG

Divarasib

Divarasib will be administered in combination with Digoxin and Rosuvastatin as specified for the respective period

DRUG

Rosuvastatin

Rosuvastatin will be administered together with Digoxin as a drug cocktail as specified for the respective period

Trial Locations (1)

32117

Daytona Beach Clinical Rsch Unit, Daytona Beach

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY