2,433
Participants
Start Date
June 30, 2025
Primary Completion Date
January 31, 2031
Study Completion Date
April 30, 2031
Higher Platelet Transfusion Threshold
Infants randomized to this arm will be monitored for a platelet transfusion threshold of 50 x 10\^9/L during postnatal days 1-7, and then for a platelet transfusion threshold of 35 x 10\^9/L at 8 or more postnatal days of life. Infants will remain on this protocol-driven threshold through 40 0/7 weeks postmenstrual age. The platelet dose will be 10 ml/kg administered over 60-120 minutes.
Lower Platelet Transfusion Threshold
Infants randomized to this arm will be monitored for a platelet transfusion threshold of 25 x 10\^9/L during postnatal days 1-7, and then for a platelet transfusion threshold of 20 x 10\^9/L at 8 or more postnatal days of life. Infants will remain on this protocol-driven threshold through 40 0/7 weeks postmenstrual age. The platelet dose will be 10 ml/kg administered over 60-120 minutes.
NOT_YET_RECRUITING
University of Rochester, Rochester
NOT_YET_RECRUITING
University of Pennsylvania, Philadelphia
NOT_YET_RECRUITING
Duke University, Durham
NOT_YET_RECRUITING
Emory University, Atlanta
NOT_YET_RECRUITING
University of Alabama at Birmingham, Birmingham
NOT_YET_RECRUITING
Vanderbilt University, Nashville
NOT_YET_RECRUITING
Nationwide Children's Hospital, Columbus
NOT_YET_RECRUITING
Case Western Reserve University, Rainbow Babies and Children's Hospital, Cleveland
RECRUITING
Cincinnati Children's Medical Center, Cincinnati
NOT_YET_RECRUITING
University of Iowa, Iowa City
RECRUITING
Northwestern Lurie Children's Hospital of Chicago, Chicago
NOT_YET_RECRUITING
University of Texas Southwestern Medical Center at Dallas, Dallas
NOT_YET_RECRUITING
University of Texas Health Science Center at Houston, Houston
NOT_YET_RECRUITING
Pediatrix Medical Group, San Antonio
NOT_YET_RECRUITING
University of Colorado, Aurora
RECRUITING
University of Utah, Salt Lake City
NOT_YET_RECRUITING
University of New Mexico, Albuquerque
NOT_YET_RECRUITING
Sharp Mary Birch Hospital for Women & Newborns, San Diego
NOT_YET_RECRUITING
Stanford University, Palo Alto
NOT_YET_RECRUITING
Beth Israel Deaconess Medical Center, Boston
National Heart, Lung, and Blood Institute (NHLBI)
NIH
NICHD Neonatal Research Network
NETWORK