Avacopan in Crescentic Immunoglobulin A Nephropathy (IgAN)

Avacopan is a complement 5a receptor (C5aR) antagonist, orally active.

0.4 mg/kg per day (maximum, 32 mg/day) for 2 months followed by dose tapering by 4 mg per day each month (total duration 6-9 months

Methylprednisolone 1g intravenous on day +1

Prednisone 0.2 mg/kg per day (maximum, 16 mg/day) for 2 months followed by dose tapering by 2 mg per day each month (total duration 6-9 months)