Neoadjuvant Toripalimab and Radiotherapy Treatment in N+ HR+ Breast Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

December 26, 2024

Primary Completion Date

November 1, 2026

Study Completion Date

November 1, 2027

Conditions
Breast Adenocarcinoma
Interventions
RADIATION

SBRT

Target the primary tumor region with a single dose of 8Gy, or deliver a dose of 3Gy to the axillary lymph nodes, administered once a day for three consecutive days.

DRUG

Immuno-chemotherapy

Standard new adjuvant treatment with toripalimab combined with chemotherapy, that is in the first phase consisting of paclitaxel and toripalimab for four cycles, followed by epirubicin, cyclophosphamide, and toripalimab for another four cycles.

Trial Locations (1)

Unknown

RECRUITING

2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou

All Listed Sponsors
lead

Second Affiliated Hospital, School of Medicine, Zhejiang University

OTHER