ID93/GLA-SE Vaccination + BCG Challenge

NARecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 18, 2024

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2027

Conditions
Tuberculosis
Interventions
BIOLOGICAL

ID93/GLA-SE

"ID93/GLA-SE is a protein-adjuvant vaccine which has been purposefully designed to elicit a diverse immune response against M.tb bacterial antigens, improve treatment outcomes and prevent TB disease in people already infected with M.tb.~ID93/GLA-SE will be administered intramuscularly."

BIOLOGICAL

BCG Danish

"BCG Danish 1331 is on the WHO list of pre-qualified vaccines and has a well-defined side effect profile. BCG is licensed for delivery via the intradermal route. It is not licensed for delivery via the aerosol route.~For the challenge, aerosol BCG will be administered via nebulizer."

Trial Locations (1)

OX3 7LE

RECRUITING

Centre for Clinical Vaccinology and Tropical Medicine, Oxford

All Listed Sponsors
lead

University of Oxford

OTHER