TPC Combined With Cadonilimab VS. TPC Alone in Anti-PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

October 21, 2024

Primary Completion Date

October 21, 2025

Study Completion Date

October 21, 2026

Conditions
Nasopharyngeal Cancinoma (NPC)
Interventions
DRUG

TPC chemotherapy

The TPC regimen included NAB-paclitaxel administered at a dose of 200 mg/m2 on day 1, cisplatin at a dose of 60 mg/m2 on day 1, and capecitabine at a dose of 1000 mg/m2, taken orally twice a day on days 1 to 14, for each cycle

DRUG

cadonilimab combined TPC chemotherapy

Cadonilimab was intravenously given at dose of 10 mg/kg on day 1. The TPC regimen included NAB-paclitaxel administered at a dose of 200 mg/m2 on day 1, cisplatin at a dose of 60 mg/m2 on day 1, and capecitabine at a dose of 1000 mg/m2, taken orally twice a day on days 1 to 14, for each cycle

Trial Locations (1)

510060

SunYat-senU, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER