Study on Hibernation-like Therapy Based on Mechanical Thrombectomy

PHASE1RecruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

November 9, 2024

Primary Completion Date

January 31, 2025

Study Completion Date

February 28, 2025

Conditions
Acute Ischemic Stroke
Interventions
DRUG

chlorpromazine and promethazine

C+P were diluted to 50 ml saline solution and delivered intravenously at the beginning of endovascular thrombectomyat a velocity of 4ml/h. The whole period of drug delivery lasts for approximately 12h.

DRUG

Placebo group

50 ml saline solution was set as placebo and delivered intravenously at the beginning of endovascular thrombectomyat a velocity of 4ml/h. The whole period of drug delivery lasts for approximately 12h.

PROCEDURE

endovascular thrombectomy

All patients that are eligible for endovascular thrombectomy will receive this surgery in aim to remove thrombus and restore reperfusion.

DRUG

rt-PA

All patients that are eligible for Intravenous thrombolysis will receive 0.9mg/kg rt-PA in aim to remove thrombus and restore reperfusion

Trial Locations (1)

276000

RECRUITING

Linyi People's Hospital, Linyi

All Listed Sponsors
collaborator

Linyi People's Hospital

OTHER

lead

Capital Medical University

OTHER