200
Participants
Start Date
January 31, 2025
Primary Completion Date
January 31, 2027
Study Completion Date
June 30, 2029
treatment withdrawal
Patients will STOP their DMT
Usual DMT continuation
Patients will continue their DMT during the trial as usual : Interferon-β (IFN-β), glatiramer acetate, dimethyl fumarate, teriflunomide or diroximel fumarate
MRI
Cerebral+spinal cord enhanced MRI (M0) Cerebral enhanced MRI (M6, Relapse early visit) Unenhanced cerebral MRI (M12, M18, M24, Relapse distant visit
Quality of Life questionnaires
EQ-5D5L: EuroQol-5-Dimension 5 levels Burden of Treatment Questionnaire (BTQ self-administered questionnaires) Hospital Anxiety and Depression (HAD) questionnaire
Disability evaluation tests
EDSS: Expanded Disability Status Scale 25Foot/Walk 9-HPT:Nine Hole Peg Test
Assistance Publique des Hôpitaux de Marseille (APHM)-Hôpital La Timone Adultes, Marseille
CHU de Caen-Hôpital Côte de Nacre, Caen
CHU de Dijon-Hôpital du Bocage, Dijon
CHU de Nîmes, Nîmes
CHU de Bordeaux-Hôpital Pellegrin, Bordeaux
CHU de Montpellier-Hôpital G. De Chauliac, Montpellier
CHU de Rennes-C.H.R. Pontchaillou, Rennes
CHU de Tours, Tours
CHU de Grenoble Alpes, La Tronche
CHU de Nancy -Hôpital Central, Nancy
Groupement des Hôpitaux de l'Institut Catholique de Lille Hôpital Saint Vincent de Paul, Lille
CHU de Lille-Hôpital Roger Salengro, Lille
CHU de Clermont-Ferrand-Hôpital Gabriel Montpied, Clermont-Ferrand
Les Hôpitaux Universitaires de Strasbourg, Strasbourg
Assistance Publique des Hôpitaux de Paris (APHP)-Hôpital Pitié-Salpêtrière, Paris
Fondation Ophtalmologique Rothschild, Paris
CHU de Rouen-Hôpital Charles Nicolle, Rouen
CHU de Limoges-Hôpital Dupuytren, Limoges
Assistance Publique des Hôpitaux de Paris (APHP)-Hôpital Henri Mondor, Créteil
CH de Gonesse, Gonesse
CHU de Nice-Hôpital Pasteur, Nice
CHU Nantes -CIC de Neurologie, Saint-Herblain
Ministry of Health, France
OTHER_GOV
University Hospital, Strasbourg, France
OTHER