RC48 Monotherapy or Combination With Envafolimab for CDK12 Alterations mCRPC With Standard Treatment Failure

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

September 24, 2024

Primary Completion Date

May 31, 2027

Study Completion Date

August 31, 2027

Conditions
Prostate CancerCDK12 Gene Mutation
Interventions
DRUG

RC48

During the patient treatment phase, the subjects received intravenous infusion of Disitamab Vedotin(RC48) (2.0 mg/kg) every 2 weeks until disease progression or death occurred.

DRUG

Envafolimab

During the treatment phase of the patient, the subjects received subcutaneous injections of Envafolimab (400 mg) every 3 weeks until the patient experienced disease progression or death.

Trial Locations (1)

300211

RECRUITING

Tianjin Medical Unversity Second Hospital, Tianjin

All Listed Sponsors
lead

Tianjin Medical University Second Hospital

OTHER