Esophageal Replacement With a Decellularized Human Esophagus Graft

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

January 1, 2030

Study Completion Date

January 1, 2030

Conditions
Esophageal Stenosis
Interventions
OTHER

Replacement of the esophagus with a decellularized human esophagus graft

The Decellularized Human Esophagus (DHE) will be surgically implanted under general anesthesia via right or left thoracotomy or cervicotomy, depending on the location of the stenosis, to replace the esophageal defect created by resection of the stenosis. An omentoplasty is performed laparoscopically beforehand to provide secondary coverage of the graft area. A temporary esophageal stent is placed endoscopically to cover the DHE and the two anastomoses for a period of 3 months, to prevent the development of an anastomotic fistula and stenosis of the graft area.

All Listed Sponsors
lead

Assistance Publique - Hôpitaux de Paris

OTHER

NCT06662370 - Esophageal Replacement With a Decellularized Human Esophagus Graft | Biotech Hunter | Biotech Hunter