Exploratory Study on the Safety and Efficacy of Disitamab Vedotin in Combination with Anlotinib Hydrochloride for the Treatment of HER-2-expressing Recurrent Platinum-resistant Ovarian Cancer.

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

5

Participants

Timeline

Start Date

October 15, 2024

Primary Completion Date

September 1, 2025

Study Completion Date

October 15, 2025

Conditions
Ovarian Cancer Recurrent
Interventions
DRUG

Disitamab Vedotin in Combination With Anlotinib Hydrochloride

"The dose of Disitamab Vedotin(RC48) is 2.0 mg/kg iv q2w d1; The dose of Anlotinib Hydrochloride Capsules is 10mg po qd (recommended to be taken before meals and at the same time every day), taken orally continuously for 2 weeks and stopped for 1 week, with a treatment cycle of 21 days.~Main research endpoint: Objective response rate (ORR)~Secondary study endpoint:~1. Progression free survival (PFS)~2. Overall survival (OS)~3. Disease Control Rate (DCR)~4. Objective Duration of Response (DoR)"

Trial Locations (1)

Unknown

RECRUITING

Xiangya Second Hospital of Central South University, Changsha

All Listed Sponsors
lead

Second Xiangya Hospital of Central South University

OTHER