Response to Exercise and Nitric Oxide in PAD

PHASE2RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

January 23, 2025

Primary Completion Date

July 1, 2029

Study Completion Date

October 1, 2029

Conditions
Peripheral Artery DiseaseExerciseIntermittent ClaudicationNitric Oxide
Interventions
BEHAVIORAL

Supervised Treadmill Exercise

This is a 12 week intervention where participants will walk for exercise 3 times a week on a treadmill at a center while being supervised by healthcare personnel.

BEHAVIORAL

Attention Control

This group will attend weekly one-hour educational sessions either on Zoom or in-person for 12 weeks. These sessions are on topics of interest to the typical PAD patient and may be led by study staff, physicians, or other health care workers.

COMBINATION_PRODUCT

Nitrate-Rich Beetroot Juice + supervised exercise therapy

Participants randomized to this group will drink nitrate-rich beetroot juice while engaged in supervised exercise.

COMBINATION_PRODUCT

Placebo + supervised exercise therapy

Participants randomized to this group will drink placebo while engaged in supervised exercise.

Trial Locations (2)

60611

RECRUITING

Northwestern University Feinberg School of Medicine, Chicago

60637

NOT_YET_RECRUITING

University of Chicago, Chicago

All Listed Sponsors
collaborator

National Institute on Aging (NIA)

NIH

lead

Northwestern University

OTHER