Efficacy and Safety of Telitacicept in IgAN

NARecruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

December 6, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
IgA Nephropathy (IgAN)Kidney DiseasesTelitaciceptGlucocorticoid
Interventions
DRUG

Telitacicept 240mg

Patients in telitacicept group will be treated with maximum tolerable dose of angiotensin converting enzyme inhibitor ( ACEI ) and/or angiotensin II receptor blocker ( ARB ) combined with telitacicept. 240 mg telitacicept will be used once a week for 40 weeks.

DRUG

Glucocorticoid

Patients in glucocorticoid group will be treated with ACEI/ARB and glucocorticoid ( prednisone/prednisolone) 0.5mg/kg (maximum 40mg/d). After 8 weeks, reduce the dosage by 5 mg per month for a total of 28-40 weeks.

Trial Locations (1)

200025

RECRUITING

Ruijin Hospital, Shanghai

All Listed Sponsors
collaborator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

RenJi Hospital

OTHER

collaborator

Sichuan Provincial People's Hospital

OTHER

collaborator

Renmin Hospital of Wuhan University

OTHER

collaborator

Shanghai 6th People's Hospital

OTHER

collaborator

Shanghai Longhua Hospital

UNKNOWN

collaborator

Huashan Hospital

OTHER

collaborator

Shanghai Changzheng Hospital

OTHER

collaborator

Wannan Medical College Yijishan Hospital

OTHER

collaborator

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

OTHER

collaborator

Songjiang Hospital Affiliated to Shanghai Jiaotong University School of Medicine

OTHER_GOV

lead

Ruijin Hospital

OTHER