Primary Progressive Aphasia Multicomponent Language Treatment Study

NAEnrolling by invitationINTERVENTIONAL
Enrollment

21

Participants

Timeline

Start Date

May 2, 2023

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Primary Progressive AphasiaSemantic DementiaSemantic Memory DisorderLogopenic Progressive AphasiaNonfluent Aphasia, ProgressiveAphasiaAphasia, Progressive
Interventions
BEHAVIORAL

Multicomponent Lexical Retrieval Training (Multi-LRT)

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing names of personally relevant target in multiple communication modalities. Treatment focuses on the use of strategies which capitalize on residual linguistic ability and autobiographical memory to support word retrieval. The participant completes two one-hour-long sessions per week plus daily homework. The participant also meets 4 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

BEHAVIORAL

Multicomponent Video Implemented Script Training in Aphasia (Multi-VISTA)

In person or via teletherapy: A multi-component treatment incorporating elements of restitutive, compensatory, and care-partner focused interventions. Participants work on producing personally relevant scripts of 3-5 sentences in length. Length and complexity of scripts are individually tailored. The participant completes 30 minutes per day of home practice, during which they speak in unison with a video/audio model of a healthy speaker clearly articulating the scripts. Biweekly (one hour each) sessions with a clinician are held which target clear and accurate script production, script memorization, and conversational usage of the script and multimodal communication. The participant also meets 6 times during the course of treatment with a study partner (e.g., spouse) for communication counseling, education, and practice of communication strategies.

BEHAVIORAL

Multicomponent Communication Partner Training (Multi-CPT)

In person or via teletherapy: A multi-component treatment incorporating elements of compensatory and care-partner focused interventions. Biweekly (one hour each) sessions with a clinician are held which target use of communication strategies including multimodal communication for the participant and study partner (e.g., spouse). The participant also completes regular assignments meant to increase generalization of communication strategies and progress on personal goals.

Trial Locations (1)

78712

University of Texas, Austin

All Listed Sponsors
collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

NIH

lead

University of Texas at Austin

OTHER