Orelabrutinib in Combination with R-CHOP for CD5-positive DLBCL Patients(Rocket Trial)

PHASE2RecruitingINTERVENTIONAL
Enrollment

39

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

November 1, 2026

Study Completion Date

March 1, 2027

Conditions
Diffuse Large B Cell Lymphoma (DLBCL)
Interventions
DRUG

Orelabrutinib Oral Tablet

Orelabrutinib (150 mg po D1-D21) is added from the second cycle of R-CHOP regimen

DRUG

R-CHOP Protocol

Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone

Trial Locations (11)

51000

RECRUITING

Sun Yat-sen Universitiy Cancer Center, Sun Yat-Sen University,, Guangzhou

510060

RECRUITING

Dongguan People's Hospital, Dongguan

RECRUITING

Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou

RECRUITING

Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai

Unknown

RECRUITING

Gansu Cancer Hospital, Lanzhou

RECRUITING

First People's Hospital of Guangzhou, Guangzhou

RECRUITING

Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou

RECRUITING

Second Affiliated Hospital of Guangzhou Medical University, Guangzhou

RECRUITING

First Affiliated Hospital of Shantou University Medical College., Shantou

RECRUITING

Shenzhen People's Hospital, Shenzhen

RECRUITING

Zhaoqing First People's Hospital, Zhaoqing

All Listed Sponsors
collaborator

Fifth Affiliated Hospital, Sun Yat-Sen University

OTHER

collaborator

Gansu Cancer Hospital

OTHER

collaborator

First Affiliated Hospital of Shantou University Medical College

OTHER

collaborator

Southern Medical University, China

OTHER

collaborator

Guangdong Provincial Hospital of Traditional Chinese Medicine

OTHER

collaborator

Second Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Fifth Affiliated Hospital of Guangzhou Medical University

OTHER

collaborator

Shenzhen People's Hospital

OTHER

collaborator

Guangzhou First People's Hospital

OTHER

collaborator

Dongguan People's Hospital

OTHER_GOV

collaborator

The First People's Hospital of Zhaoqing

UNKNOWN

lead

Sun Yat-sen University

OTHER