40
Participants
Start Date
February 1, 2025
Primary Completion Date
May 1, 2026
Study Completion Date
August 31, 2026
Euthyrox (levothyroxine)
Euthyrox (levothyroxine sodium tablets; L-T4) is a thyromimetic synthetic drug identical to T4. Patients will recieve levothyroxine (euthyrox) in a dose of 2 μg × kg body weight / day.
Cytomel (liothyronine)
Cytomel (liothyronine sodium tablets; L-T3) is a thyromimetic synthetic drug identical to T3. The pharmacoequivalent ratio of L-T3 to L-T4 is 1:3. The L-T4-cohort receive doses of 2 μg × kg body weight / day. The pharmacoequivalent L-T3 dose would be 1/3th of that namely: 0.67 μg × kg body weight / day. Cytomel will be given trice daily and available dosages are 5, 12.5 and 25 μg.
University Medical Center Groningen (UMCG), Groningen
Radboud University Nijmegen, Nijmegen
Radboud University Medical Center
OTHER
University Medical Center Groningen
OTHER