Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

October 30, 2024

Primary Completion Date

October 30, 2028

Study Completion Date

October 30, 2029

Conditions
Unresectable Metastatic Colorectal Cancer
Interventions
DRUG

Avastin, 25 Mg/mL Intravenous Solution

"Experimental group/ Patients randomized to the experimental group of the trial will receive bevacizumab as an IV infusion at a dose of 10 mg/kg, administered in 2 preparations of 5 mg/kg, every 2 weeks. Patients will receive treatment until progression, patient refusal, or unacceptable toxicity.~Control group: Patients randomized to the control group of the trial will receive bevacizumab at a dose of 5 mg/kg and placebo (NaCl) every two weeks. Patients will receive treatment until progression, patient refusal, or unacceptable toxicity."

All Listed Sponsors
collaborator

CHU DE BESANCON

UNKNOWN

collaborator

Gustave Roussy, Cancer Campus, Grand Paris

OTHER

collaborator

CHU de Clermont-Ferrand

UNKNOWN

collaborator

CHU de Reims

OTHER

collaborator

CHU de Brest

UNKNOWN

collaborator

AP-HP, Hôpital Pitié- Salpétrière

UNKNOWN

collaborator

University Hospital, Rouen

OTHER

collaborator

Poitiers University Hospital

OTHER

collaborator

Institut Paoli-Calmettes

OTHER

collaborator

Rennes University Hospital

OTHER

collaborator

University Hospital, Toulouse

OTHER

collaborator

AP-HP, Hôpital Saint-Louis

UNKNOWN

collaborator

HCL Hôpital Edouard Hériot

UNKNOWN

collaborator

Centre Hospitalier Universitaire Dijon

OTHER

collaborator

Nantes University Hospital

OTHER

collaborator

Centre Hospitalier Universitaire, Amiens

OTHER

collaborator

Hôpital Privé Jean Mermoz

UNKNOWN

collaborator

AP-HP, Hôpital Henri Mondor

UNKNOWN

collaborator

AP-HP, Hôpital Paul Brousse

UNKNOWN

collaborator

CHG de St-Malo

UNKNOWN

collaborator

Polyclinique de Blois

UNKNOWN

collaborator

University Hospital, Caen

OTHER

collaborator

Central Hospital, Nancy, France

OTHER

lead

University Hospital, Tours

OTHER

NCT06642844 - Bevacizumab-based Chemotherapy Adapted to Bevacizumab Pharmacokinetics in 1st-line Treatment | Biotech Hunter | Biotech Hunter