Study of TPEx Followed by a Maintenance With Avelumab and Cetuximab in First Line Recurrent or Metastatic Squamous Cell Carcinoma of the H&N

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

January 2, 2025

Primary Completion Date

October 2, 2027

Study Completion Date

December 2, 2028

Conditions
Recurrent or Metastatic Squamous Cell Carcinoma of Head and Neck
Interventions
DRUG

Avelumab administration at 10mg/kg

"Maintenance (until progression, unacceptable toxicity or if CR \> 1 year, as per investigator choice)~Avelumab 10 mg/kg every 2 weeks (±3 days)"

DRUG

Cetuximab (Erbitux)

"Maintenance (until progression, unacceptable toxicity or if CR \> 1 year, as per investigator choice)~Cetuximab 500 mg/m² every 2 weeks (±3 days) (according to current recommendations \[35\])"

Trial Locations (1)

54519

RECRUITING

Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy

All Listed Sponsors
lead

Groupe Oncologie Radiotherapie Tete et Cou

OTHER