60
Participants
Start Date
October 12, 2024
Primary Completion Date
October 14, 2026
Study Completion Date
December 31, 2026
Lactobacillus paracasei LC19 supplementation
Orally administered Lactobacillus paracasei LC19 strain product, in addition to lifestyle intervention. This product is a probiotic milk powder, and the Lactobacillus paracasei LC19 strain is capable of producing high levels of tryptophan-conjugated cholic acid (Trp-CA)( 25g/packet, 2 packets/day).
Placebo probiotic milk powder
Orally administered placebo probiotic milk powder, in addition to lifestyle intervention. The placebo probiotic strain also belongs to Lactobacillus paracasei species, but does not produce Trp-CA. These products have the same color, odor, appearance, and packaging (25g/packet, 2 packets/day).
RECRUITING
Beijing Chao-yang Hospital, Capital Medical University, Beijing
Beijing Chao Yang Hospital
OTHER