A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Patients With Bladder Cancer (MK-2870-027)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

December 20, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

July 31, 2028

Conditions
Non-Muscle Invasive Bladder Cancer
Interventions
DRUG

Sacituzumab tirumotecan

Intravesical administration

DRUG

Rescue medication

Participants are allowed to take rescue medication for stomatitis or oral mucositis. At the discretion of the investigator, participants are provided with a prescription for rescue medications. Recommended rescue medications are antihistamine, histamine-2 (H2) receptor antagonist, acetaminophen or equivalent, dexamethasone or equivalent infusion or steroid mouthwash (dexamethasone or equivalent), antiemetic medications, oral nystatin suspension or antifungal medications, antidiarrheal agents, antiemetic agents, opiate and non-opiate analgesic agents, appetite stimulants, and granulocyte and erythroid growth factors.

DRUG

Supportive care measures

Participants are allowed to take supportive care measures for the management of adverse events associated with study intervention at the discretion of the investigator. Artificial tear drops or gel may be given as a supportive care for Ocular Surface Toxicity.

Trial Locations (13)

21287

RECRUITING

Johns Hopkins University ( Site 0055), Baltimore

28041

RECRUITING

Hospital Universitario 12 de Octubre ( Site 0042), Madrid

29010

RECRUITING

Hospital Universitario Virgen de la Victoria ( Site 0043), Málaga

33612

RECRUITING

Moffitt Cancer Center ( Site 0057), Tampa

59037

RECRUITING

Hôpital Claude Huriez ( Site 0012), Lille

60611

RECRUITING

Northwestern University ( Site 0051), Chicago

93301

RECRUITING

Michael G Oefelein Clinical Trials ( Site 0053), Bakersfield

94010

RECRUITING

HENRI MONDOR HOSPITAL ( Site 0011), Créteil

94805

RECRUITING

Gustave Roussy ( Site 0013), Villejuif

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre ( Site 0003), Toronto

J1H 5N4

RECRUITING

CIUSSS de l'Estrie-CHUS ( Site 0002), Sherbrooke

3015 GD

RECRUITING

Erasmus Medisch Centrum ( Site 0032), Rotterdam

EC1A 7BE

RECRUITING

St Bartholomew s Hospital ( Site 0061), London

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY