288
Participants
Start Date
March 28, 2025
Primary Completion Date
November 30, 2028
Study Completion Date
November 30, 2028
Typhoid VI Polysaccharide Vaccine Injectable Solution
Salmonella typhi capsular polysaccharide vaccine (Typhoid Vi Polysaccharide Vaccine): Each dose of 0.5ml Salmonella typhi capsular polysaccharide vaccine (Sanofi Pasteur, SA) is formulated to contain 25μg of purified Vi polysaccharide in a colorless isotonic phosphate buffered saline (pH 7±0.3), 4.150mg of sodium chloride, 0.065mg of disodium phosphate, 0.023mg of monosodium phosphate and 0.5ml of sterile water for injection. It is indicated for use by humans aged 2 years and older for protection against typhoid fever.
Saline Placebo (0.5mL injection)
The placebo injection will consist of 0.5mL of saline.
RECRUITING
San Francisco VA Health Care System, San Francisco
National Institute of Mental Health (NIMH)
NIH
Northern California Institute of Research and Education
OTHER
San Francisco Veterans Affairs Medical Center
FED
University of California, San Francisco
OTHER