NCT06630325 - A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 24, 2025

Primary Completion Date

December 31, 2027

Study Completion Date

June 30, 2033

Conditions

Advanced Breast CarcinomaAdvanced Malignant Solid NeoplasmAdvanced Ovarian CarcinomaAdvanced Pancreatic CarcinomaAdvanced Prostate CarcinomaAdvanced SarcomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Stage III Ovarian Cancer AJCC v8Stage III Pancreatic Cancer AJCC v8Stage III Prostate Cancer AJCC v8Stage IV Ovarian Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8Stage IV Prostate Cancer AJCC v8

Interventions

DRUG

Abemaciclib

Given PO

PROCEDURE

Biopsy

Undergo tumor biopsy

PROCEDURE

Bone Scan

Undergo bone scan

DRUG

Carboplatin

Given IV

PROCEDURE

Echocardiography

Undergo echocardiography

DRUG

Exemestane

Given PO

DRUG

Fulvestrant

Given IM

DRUG

Gefitinib

Given PO

DRUG

Gemcitabine

Given IV

DRUG

Letrozole

Given PO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Olaparib

Given PO

DRUG

Osimertinib

Given PO

DRUG

Paclitaxel

Given IV

DRUG

Pegylated Liposomal Doxorubicin Hydrochloride

Given IV

DRUG

Pemetrexed

Given IV

OTHER

Survey Administration

Ancillary studies

DRUG

Tamoxifen

Given PO

DRUG

Temozolomide

Given PO

PROCEDURE

Biospecimen Collection

Biological Sample Collection, Biological Sample Collection, Biospecimen Collected, Biospecimen Collection, Specimen Collection

Trial Locations (1)

97239

RECRUITING

OHSU Knight Cancer Institute, Portland