Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

PHASE1RecruitingINTERVENTIONAL
Enrollment

392

Participants

Timeline

Start Date

October 29, 2024

Primary Completion Date

November 30, 2028

Study Completion Date

November 30, 2028

Conditions
Solid Tumor, AdultMetastatic Breast CancerAdvanced Breast CancerHER2 Mutation-Related TumorsHER2-positive Metastatic Breast CancerKRAS Mutant Metastatic Colorectal CancerMetastatic Lung CancerMetastatic Colorectal CancerAdvanced Lung CancerHR-positive, HER2-negative Advanced Breast CancerHER2-positive Advanced Breast Cancer
Interventions
DRUG

BBO-10203

Participants will receive assigned dose of BBO-10203 orally once daily

DRUG

Trastuzumab

Participants will receive trastuzumab as infusion or subcutaneous injection every 21 days

DRUG

Fulvestrant

Patients will receive Fulvestrant as an intramuscular injection every 28 days (additional dose on C1D15)

DRUG

Ribociclib

Patients will receive Ribociclib orally once a day (21 days on treatment, 7 days off)

DRUG

FOLFOX

Patients will receive FOLFOX as infusion every 14 days

DRUG

Bevacizumab

Patients will receive bevacizumab as infusion every 28 days

Trial Locations (15)

2031

RECRUITING

Scientia Clinical Research, Randwick

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

10032

RECRUITING

Columbia University Irving Medical Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

33612

RECRUITING

Moffitt Cancer Center, Tampa

37203

RECRUITING

SCRI Oncology Partners, Nashville

46202

RECRUITING

Indiana University Simon Comprehensive Cancer Center, Indianapolis

75230

RECRUITING

SCRI at Mary Crowley, Dallas

75390

RECRUITING

University of Texas Southwestern Medical Center, Dallas

77030

RECRUITING

The University of Texas MD Anderson Cancer Center, Houston

78229

RECRUITING

University of Texas San Antonio (UTSA), San Antonio

90095

RECRUITING

University of California Los Angeles, Los Angeles

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

02215

RECRUITING

Dana-Farber Cancer Insitute, Boston

All Listed Sponsors
lead

TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics)

INDUSTRY