An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

195

Participants

Timeline

Start Date

August 27, 2024

Primary Completion Date

April 1, 2026

Study Completion Date

December 15, 2026

Conditions
Thyroid Eye Disease
Interventions
DRUG

VRDN-003

VRDN-003 is an investigational, subcutaneously administered, humanized monoclonal antibody directed against the Insulin-like Growth Factor-1 receptor (IGF-1R).

DRUG

Placebo

All participants will receive the same number of injections to maintain masking. Masking will be maintained by the use of placebo injections that appear identical to VRDN-003 injections.

Trial Locations (37)

19104

Scheie Eye Institute Penn Presbyterian, Philadelphia

19107

Wills Eye Hospital, Philadelphia

26506

West Virginia University Eye Institute, Morgantown

27710

Duke Eye Center, Durham

28803

Asheville Clinical Research, Asheville

30328

Agile Clinical Research Trials, LLC, Atlanta

33125

Med-Care Research, Miami

33145

Hype Clinical Research LLC, Miami

33193

Anmed Health Services LLC, Miami

33990

Southern Clinical Research LLc, Miami

34239

Sarasota Retina Institute, Sarasota

34744

Ilumina Medical Research, Kissimmee

48026

Fraser Eye Care Center, Fraser

48152

Kahana Oculoplastic & Orbital Surgery, Livonia

60462

Vision Medical Research, Orland Park

64108

University Health, Kansas City

77030

Baylor College of Medicine/Alkek Eye Center, Houston

77070

Gulf Coast Clinical Trials, Houston

77074

Neuro-Eye Clinical Trials, Houston

77429

Horizon Clinical Research Group, Cypress

85260

Scottsdale Clinical Trials, Scottsdale

89144

S.L. Office, Las Vegas

89436

Vector Clinical Trials, Sparks

90023

Advancing Research International, LLC, Los Angeles

90033

Roski Eye Institute, Keck School of Medicine, USC, Los Angeles

90262

Alliance Research Institute - Lynwood, Lynwood

90301

United Medical Research Institute, Inglewood

91101

Pasadena Clinical Trials, Pasadena

91304

Alliance Research Institute - Canoga Park, Canoga Park

92108

Senta Clinic, San Diego

92647

Marvel Clinical Research, Huntington Beach

92660

A.P.J. Office, Newport Beach

94303

Byers Eye Institute at Stanford University, Palo Alto

98104

University of Washington, Eye institute, Seattle

02114

Massachusetts Eye and Ear, Boston

02189

Opthalmic Consultants of Boston, East Weymouth

07103

Rutgers New Jersey Medical School, Newark

All Listed Sponsors
lead

Viridian Therapeutics, Inc.

INDUSTRY

NCT06625398 - An Efficacy, Safety, and Tolerability Study of VRDN-003 in Participants With Chronic Thyroid Eye Disease (TED) | Biotech Hunter | Biotech Hunter