Randomized Trial of SGLT2i in Heart Transplant Recipients

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

January 2, 2026

Primary Completion Date

August 31, 2029

Study Completion Date

February 28, 2030

Conditions
Heart TransplantCardiovascular DiseaseKidney Disease
Interventions
DRUG

Empagliflozin

A starting dose of empagliflozin 10 mg or matching placebo will be initiated after randomization and completion of the baseline testing. Participating subjects will remain at this dose for the whole study duration of 12 months.

DRUG

Placebo

A starting dose of empagliflozin 10 mg or matching placebo will be initiated after randomization and completion of the baseline testing. Participating subjects will remain at this dose for the whole study duration of 12 months.

Trial Locations (6)

94304-1207

VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto

37212-2637

Tennessee Valley Healthcare System Nashville Campus, Nashville, TN, Nashville

77030-4211

Michael E. DeBakey VA Medical Center, Houston, TX, Houston

84148-0001

VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City

23249-0001

Hunter Holmes McGuire VA Medical Center, Richmond, VA, Richmond

53705-2254

William S. Middleton Memorial Veterans Hospital, Madison, WI, Madison

All Listed Sponsors
lead

VA Office of Research and Development

FED