A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

PHASE1RecruitingINTERVENTIONAL
Enrollment

50

Participants

Timeline

Start Date

April 28, 2025

Primary Completion Date

March 31, 2030

Study Completion Date

March 31, 2030

Conditions
Lymphoma
Interventions
DRUG

Glofitamab

Participants will receive IV glofitamab for up to 12 cycles (cycle length = 21 days)

DRUG

Tocilizumab

Participants will receive IV tocilizumab as needed to manage cytokine release syndrome (CRS)

DRUG

Obinutuzumab

Participants will receive IV obinutuzumab pretreatment

DRUG

Gemcitabine

Participants will receive IV gemcitabine for up to 8 cycles (cycle length = 21 days)

DRUG

Oxaliplatin

Participants will receive IV oxaliplatin for up to 8 cycles (cycle length = 21 days)

Trial Locations (14)

19107

RECRUITING

Thomas Jefferson University, Philadelphia

20007

RECRUITING

Georgetown University, Washington D.C.

20814

RECRUITING

Walter Reed National Military Medical Center, Bethesda

30329

RECRUITING

Winship Cancer Institute of Emory University, Atlanta

32804

RECRUITING

AdventHealth Cancer Institute, Orlando

60612

RECRUITING

University of Illinois Cancer Center, Chicago

64128

RECRUITING

Kansas City VA Medical Center, Kansas City

77030

RECRUITING

Baylor College of Medicine, Houston

77380

RECRUITING

Renovatio Clinical, The Woodlands

79915

RECRUITING

Renovatio Clinical - El Paso, El Paso

87505

RECRUITING

Christus Health - Christus St. Vincent Regional Medical Center, Santa Fe

92093

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

92653

RECRUITING

Saddleback Memorial Medical Center, Laguna Hills

90404-2023

RECRUITING

University of California Los Angeles (UCLA) - Cancer Care - Santa Monica, Santa Monica

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY