42
Participants
Start Date
October 1, 2024
Primary Completion Date
December 1, 2026
Study Completion Date
August 30, 2027
Transjugular intrahepatic portosystemic shunt
A needle punctured the portal vein through the transjugular approach. After a successful puncture, the parenchymal tract was dilated, and covered stents were introduced. The specifications of the covered stents were 8 mm × 50 mm, 8 mm × 60 mm, 8 mm × 70 mm, and 8 mm × 80 mm. All of the diameters of the bare stents were 8 mm, and the lengths were 50-80 mm. The portal vein pressure was measured before and after shunt creation. After the insertion of TIPS, all of the participants received a diuretic treatment and a salt-limited diet.
Lenvatinib
12 mg (body weight ≥60 kg) , 8 mg (body weight \<60 kg
PD-1 inhibitor
Tislelizumab (200mg intravenously every 3 weeks), Sintilimab (200mg intravenously every 3 weeks), Camrelizumab (200mg intravenously every 3 weeks)
RECRUITING
Chinese PLA General hospital, Beijing
Chinese PLA General Hospital
OTHER
Sun Yat-sen University
OTHER