NCT06620302 - Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 12, 2025

Primary Completion Date

December 30, 2031

Study Completion Date

December 30, 2031

Conditions

Childhood Fibrolamellar CarcinomaRecurrent Childhood Fibrolamellar CarcinomaRecurrent Childhood Malignant Solid NeoplasmRecurrent Fibrolamellar CarcinomaRecurrent Malignant Solid NeoplasmRefractory Childhood Fibrolamellar CarcinomaRefractory Childhood Malignant Solid NeoplasmRefractory Fibrolamellar CarcinomaRefractory Malignant Solid Neoplasm

Interventions

BIOLOGICAL

Bcl-XL Proteolysis Targeting Chimera DT2216

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Irinotecan

Given IV

Trial Locations (18)

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

20010

RECRUITING

Children's National Medical Center, Washington D.C.

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

63110

RECRUITING

Washington University School of Medicine, St Louis

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

80045

RECRUITING

Children's Hospital Colorado, Aurora

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

92868

RECRUITING

Children's Hospital of Orange County, Orange

98105

RECRUITING

Seattle Children's Hospital, Seattle

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

All Listed Sponsors

lead

Children's Oncology Group

NETWORK