NHFOV Vs NIPPV Post-extubation in Preterm Neonates

NACompletedINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

January 20, 2023

Primary Completion Date

January 20, 2024

Study Completion Date

January 20, 2024

Conditions
Noninvasive Ventilation
Interventions
DEVICE

noninvasive high frequency oscillation ventilation

"cases of group A extubated on NHFOV, and it will be provided by CNO, Medin device, Germany) via binasal prongs with the following parameters:~* MAP of 6 cmH2O and will be titrated targeting a FiO2 ≤ 25-30%, maximum FiO2 will be 40% and target oxygen saturation will be 90-95%.~* Frequency of 8 Hz and can be changed within the range of 8-12 Hz.~* Amplitude of 7 cmH2O and can be titrated within the range of 7-10 cmH2O according to PaCO2."

DEVICE

noninvasive positive pressure ventilation

"NIPPV will be provided by any type of neonatal ventilator available in the unit via binasal prongs starting with the following parameters:~* Positive end expiratory pressure (PEEP) of 5 cmH2O and can be titrated to 8 cmH2O according to the oxygenation .~* Peak inspiratory pressure (PIP) of 15 cmH2O and can be titrated to 25 cmH2O ,according to oxygenation , PaCO2 level and the chest expansion .~* FiO2 ≤ 25-30% and can be increased to 40 % maximally targeting oxygen saturation of 90-95% .~* Inspiratory time of 0.40-0.50 s .~* Rate of 30 bpm and can be increased to maximum 50 bpm .~* Synchronization will not be applied."

Trial Locations (1)

Unknown

Kafrelsheikh University, Kafrelsheikh

All Listed Sponsors
lead

Kafrelsheikh University

OTHER