Routine vs On-demand ECMO for Lung Transplantation

NANot yet recruitingINTERVENTIONAL
Enrollment

218

Participants

Timeline

Start Date

September 15, 2024

Primary Completion Date

October 15, 2028

Study Completion Date

December 15, 2028

Conditions
Respiratory FailureInterstitial Lung Disease (ILD)Pulmonary FibrosisCOPD (Chronic Obstructive Pulmonary Disease)
Interventions
DEVICE

Routine ECMO

Routine intraoperative venoarterial ECMO during lung transplant

DEVICE

On-demand ECMO

"Selective, indication-based intraoperative cardiopulmonary support. In this group, the transplant will be planned without cardiopulmonary support. intraoperative venoarterial ECMO will be used selectively based on hemodynamic and/or gas exchange abnormalities :~1. Inability to maintain adequate hemodynamics and stable perfusion despite volume resuscitation and vasopressor administration and in the absence of readily correctable cause~2. Inability to tolerate pulmonary artery clamping~3. Inadequate gas exchange despite attempts at the optimization of ventilator parameters and treatments related to respiratory mechanics and ventilation/perfusion matching~4. Inadequate exposure to the surgical field~5. The transplant team is concerned about the ability to maintain organ perfusion or ventilate with a lung protective strategy, even if the aforementioned criteria are unmet.~6. Concerns about donor lung quality and a desire to protect the implanted lung from single lung perfusion"

Trial Locations (4)

T6G2G3

Univeristy of Alberta & Alberta Health Services, Edmonton

Unknown

Vancouver General Hospital, Vancouver

M5G 1M1

University Health Network / Toronto General Hospiatl, Toronto

H2X3E4

Centre Hospitalier de l'Université de Montréal, Montreal

All Listed Sponsors
lead

Centre hospitalier de l'Université de Montréal (CHUM)

OTHER

NCT06615492 - Routine vs On-demand ECMO for Lung Transplantation | Biotech Hunter | Biotech Hunter