A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203)

PHASE3RecruitingINTERVENTIONAL
Enrollment

572

Participants

Timeline

Start Date

April 2, 2025

Primary Completion Date

January 17, 2031

Study Completion Date

January 17, 2031

Conditions
Graft-versus-host Disease (GVHD)
Interventions
DRUG

Tacrolimus (Tac)

Tablet or intravenously (IV)

DRUG

Methotrexate (MTX)

Intravenously (IV)

DRUG

Ruxolitinib (Rux)

Tablet

DRUG

Cyclophosphamide

Intravenously (IV)

DRUG

Mycophenolate mofetil (MMF)

Tablet or intravenously (IV)

Trial Locations (26)

10029

RECRUITING

Mount Sinai Hospital, New York

10065

RECRUITING

Memorial Sloan Kettering, New York

19104

RECRUITING

University of Pennsylvania, Philadelphia

23298

RECRUITING

Virginia Commonwealth University, North Hospital, Richmond

27514

RECRUITING

University of North Carolina At Chapel Hill, Chapel Hill

27705

RECRUITING

Duke University Medical Center, Durham

28204

RECRUITING

Levine Cancer Institute, Charlotte

29425

RECRUITING

Medical University of South Carolina, Charleston

30342

RECRUITING

Blood and Marrow Transplant Group of Georgia, Atlanta

33136

RECRUITING

University of Miami, Miami

33612

RECRUITING

Moffitt Cancer Center, Tampa

37232

RECRUITING

Vanderbilt Medical Center, Nashville

43210

RECRUITING

Ohio State University, Columbus

46202

RECRUITING

Indiana University Cancer Center, Indianapolis

48109

RECRUITING

University of Michigan, Ann Arbor

48201

RECRUITING

Karmanos Cancer Institute, Detroit

48202

RECRUITING

Henry Ford Hospital, Detroit

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

53705

RECRUITING

University of Wisconsin, Madison

63110

RECRUITING

Washington University, St Louis

66160

RECRUITING

University of Kansas Hospital Authority, Kansas City

77030

RECRUITING

Baylor College of Medicine, Houston

94304

RECRUITING

Stanford Cancer Center, Palo Alto

97239

RECRUITING

Oregon Health & Science University, Portland

98109

RECRUITING

Fred Hutchinson Cancer Research Center, Seattle

02114

RECRUITING

Massachusetts General Hospital, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Blood and Marrow Transplant Clinical Trials Network

NETWORK

collaborator

National Institutes of Health (NIH)

NIH

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

National Cancer Institute (NCI)

NIH

lead

Incyte Corporation

INDUSTRY

NCT06615050 - A Study of Tacrolimus/Methotrexate/Ruxolitinib Versus Post-Transplant Cyclophosphamide/Tacrolimus/Mycophenolate Mofetil in Non-Myeloablative/Reduced Intensity Conditioning Allogeneic Peripheral Blood Stem Cell Transplantation (BMT CTN 2203) | Biotech Hunter | Biotech Hunter