An Exploratory Clinical Study of CD19 CAR NK Cells for the Treatment of Refractory Antisynthetase Antibody Syndrome and Rheumatoid Arthritis

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

May 20, 2025

Primary Completion Date

October 20, 2025

Study Completion Date

October 20, 2026

Conditions
Antisynthetase SyndromeRheumatoid Arthritis
Interventions
BIOLOGICAL

anti CD19 CAR NK cells

This study is a single-arm, open-label and single-center exploratory clinical study to evaluate the safety and effectiveness of anti CD19 CAR NK cells in patients with refractory antisynthetase antibody syndrome (ASyS) and rheumatoid arthritis (RA). All subjects will receive fludarabine/cyclophosphamide lymphodepletion followed by Anti-CD19 CAR NK cells infusion.

Trial Locations (1)

210029

RECRUITING

The First Affiliated Hospital with Nanjing Medical University, Nanjing

All Listed Sponsors
collaborator

Rui Therapeutics Co., Ltd

INDUSTRY

lead

The First Affiliated Hospital with Nanjing Medical University

OTHER