14
Participants
Start Date
May 22, 2025
Primary Completion Date
January 31, 2027
Study Completion Date
January 31, 2027
Metformin Hydrochloride
Metformin dosage titrated from 500 mg/daily for 2 weeks, then 1000 mg/daily for 2 weeks, 1500 mg/daily for 2 weeks, and then achieving 2000 mg/daily for a duration of 6 months of treatment.
Placebo
1 tablet orally with evening meal for 2 weeks, then 1 tablet twice daily for 2 weeks, then 3 tablets split twice daily for 2 weeks, then 4 tablets split twice daily, for a total of 6 months of treatment.
RECRUITING
Boston Children's Hospital, Boston
Boston Children's Hospital
OTHER