Efficacy and Safety of TTM in Adults With ECPR.

NAActive, not recruitingINTERVENTIONAL
Enrollment

146

Participants

Timeline

Start Date

November 1, 2023

Primary Completion Date

April 30, 2026

Study Completion Date

December 31, 2026

Conditions
Cardiac Arrest
Interventions
BEHAVIORAL

hypothermia group

Minimize the temperature of the thermometric tank or thermometric catheter for rapid temperature control. Use a thermometric catheter to monitor changes in the patient's core body temperature in real time. When the core body temperature drops to 34 ℃, adjust the target temperature of the temperature-controlled water tank to 34 ℃ and adjust the target temperature of the temperature-controlled water tank in real time according to the patient's core body temperature. Keep the core body temperature around 34 ℃. Maintain the body temperature at 34℃ for at least 24 hours after the patient resumes autonomous circulation. After the patient has resumed voluntary circulation for 24 hours, the rewarming process can begin. The target temperature of the temperature control tank will increase at a rate of 0.2°C/h. After reaching 36°C, maintain the current temperature. Once 36°C is reached, the current temperature is maintained until autonomic circulation has been restored for 5 days.

BEHAVIORAL

normothermia group

Set the temperature of the temperature-controlled water tank or the in vivo cooling catheter to 37°C to maintain the patient's core temperature between 36.5-37.5°C. Real-time monitoring of the patient's core temperature changes through the thermometric urinary catheter, and real-time adjustment of the temperature of the temperature-controlled water tank. The patient's temperature was maintained between 36.5-37.5°C after the patient resumed voluntary circulation until the end of temperature control 5 days after the recovery of voluntary circulation.

Trial Locations (1)

100191

Emergency Dept of Peking University Third Hospital, Beijing

All Listed Sponsors
lead

Peking University Third Hospital

OTHER

NCT06608095 - Efficacy and Safety of TTM in Adults With ECPR. | Biotech Hunter | Biotech Hunter