Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

PHASE2RecruitingINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

August 5, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

October 31, 2027

Conditions

Refractory Metastatic Colorectal Cancer

Interventions

DRUG

Melphalan/HDS Followed by Consolidation Treatment with Trifluridine-tipiracil plus Bevacizumab

Trifluridine-tipiracil plus Bevacizumab Alone

DRUG

Trifluridine-tipiracil plus Bevacizumab Alone

Trial Locations (1)

RECRUITING

City of Hope, Duarte

All Listed Sponsors

lead

Delcath Systems Inc.

INDUSTRY