NCT06603363 - Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT | Biotech Hunter

Enrollment

140

Participants

Timeline

Start Date

May 28, 2025

Primary Completion Date

October 15, 2026

Study Completion Date

December 15, 2028

Conditions

Coronary Artery DiseaseAtherosclerotic PlaqueCoronary Computed Tomography AngiographyStatin TherapyMultidetector Computed TomographyHeart DiseasesCardiovascular DiseasesArteriosclerosisVascular DiseasesHyperlipidemia

Interventions

DRUG

Rosuvastatin 40mg

Participants will receive 40 mg of rosuvastatin once a day for 3 months. After the 3-month visit, the dose will be reduced to a dose per standard of care.

DRUG

Placebo

Participants will receive a placebo for rosuvastatin once a day for 3 months. After the 3-month visit, standard rosuvastatin will be initiated.

DIAGNOSTIC_TEST

Coronary Computed Tomography Angiography (Coronary CTA)

Computed Tomography Angiography including coronary calcium scoring and coronary computed tomography angiography at baseline, 3-month, and 24-month visits with a PCD-CT scanner.

DIAGNOSTIC_TEST

Blood test

Blood test at baseline, 3-month, and 24-month visits.

Trial Locations (1)

1082

RECRUITING

Semmelweis University, Medical Imaging Centre, Budapest