Long-term Alterations of Host-microbiome Interactions and Cardiovascular and Respiratory Diseases Progression After Pneumonia

NARecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

January 2, 2025

Primary Completion Date

January 2, 2029

Study Completion Date

May 1, 2029

Conditions
Hospital Acquired Pneumonia (HAP)Cardiovascular and Respiratory Disease
Interventions
OTHER

Blood samples

Four blood samples will be taken outside standard care for groups A, B, C and D: at inclusion, M6, M18 and M30 (only at inclusion for group C).

OTHER

Oropharyngeal swabs

An oropharyngeal swab will be taken to analyze patients\' upper airway microbiome at inclusion, M6, M18 and M30.

OTHER

Calcium score (CT scan)

A calcium score will be taken at 30 months, to assess individual cardiovascular risk.

OTHER

ECG

Performed at inclusion, M6, M18 and M30

OTHER

Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration, and 6-minute walk test

Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration, and 6-minute walk test: These tests will be performed consecutively for 2 hours at inclusion (6-minute walk test only), at M6 and at M30. These tests will be performed to assess respiratory and cardiac function.

Trial Locations (5)

Unknown

NOT_YET_RECRUITING

Angers University Hospital, Angers

RECRUITING

Nantes University Hospital, Nantes

NOT_YET_RECRUITING

Rennes University Hospital, Rennes

NOT_YET_RECRUITING

Rouen University Hospital, Rouen

NOT_YET_RECRUITING

Toulouse University Hospital, Toulouse

All Listed Sponsors
lead

Nantes University Hospital

OTHER