300
Participants
Start Date
January 2, 2025
Primary Completion Date
January 2, 2029
Study Completion Date
May 1, 2029
Blood samples
Four blood samples will be taken outside standard care for groups A, B, C and D: at inclusion, M6, M18 and M30 (only at inclusion for group C).
Oropharyngeal swabs
An oropharyngeal swab will be taken to analyze patients\' upper airway microbiome at inclusion, M6, M18 and M30.
Calcium score (CT scan)
A calcium score will be taken at 30 months, to assess individual cardiovascular risk.
ECG
Performed at inclusion, M6, M18 and M30
Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration, and 6-minute walk test
Cardiopulmonary exercise test, spirometry, plethysmography, pulmonary absorption of carbon monoxide in a single inspiration, and 6-minute walk test: These tests will be performed consecutively for 2 hours at inclusion (6-minute walk test only), at M6 and at M30. These tests will be performed to assess respiratory and cardiac function.
NOT_YET_RECRUITING
Angers University Hospital, Angers
RECRUITING
Nantes University Hospital, Nantes
NOT_YET_RECRUITING
Rennes University Hospital, Rennes
NOT_YET_RECRUITING
Rouen University Hospital, Rouen
NOT_YET_RECRUITING
Toulouse University Hospital, Toulouse
Nantes University Hospital
OTHER