Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi

RecruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Melanoma
Interventions
DRUG

Single agent, adjuvant anti-PD1 therapy

"One of the following Single-agent, adjuvant anti-PD1 therapies:~Nivolumab is a type of targeted therapy drug called an immune checkpoint inhibitor (a type of immunotherapy). It is a monoclonal antibody that binds to the protein PD-1 on the surface of immune cells called T cells. It works by keeping cancer cells from suppressing the immune system.~Dose = 240 mg IV every 2 weeks/480 mg every 4 weeks or, Pembrolizumab is a monoclonal antibody and a type of immune checkpoint inhibitor that's used in cancer immunotherapy. It works by attaching to the PD-1 protein on the surface of T cells, which are immune cells. This prevents cancer cells from suppressing the immune system, allowing the immune system to attack and kill the cancer cells.~Dose = 200 mg IV every 3 weeks/ 400 mg every 6 weeks"

Trial Locations (1)

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

Sponsors
All Listed Sponsors
collaborator

Melanoma Research Foundation

OTHER

collaborator

VeyTel Inc.

UNKNOWN

lead

John Kirkwood

OTHER