NCT06597942View on ClinicalTrials.gov

Deep Repetitive Transcranial Magnetic Stimulation (rTMS) of the Precuneus for Alzheimer Disease (AD)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

October 17, 2024

Primary Completion Date

October 31, 2026

Study Completion Date

October 31, 2026

Conditions
Alzheimer's DiseaseAlzheimer DiseaseDementia Alzheimer TypeMild Alzheimer's DiseaseModerate Alzheimer's DiseaseAlzheimer's Disease (AD)Alzheimer's Dementia
Interventions
DEVICE

TMS

rTMS Stimulation Parameters Pulse count: 1600 pulses Frequency: 20Hz Pules per train: 40 pulses Inter-train interval: 28 seconds Intensity: 100% Motor Threshold (depth-corrected from MRI) Target: Precuneus using structural MRI navigation with MNI coordinates

DEVICE

Transcranial Magnetic Stimulation Sham

Sham coil placed in same location and set with same parameters as active treatment coil. However, this device will not output active treatment and scalp electrodes will mimic the sensation of rTMS for the participant.

Trial Locations (1)

90095

RECRUITING

UCLA TMS Clinical and Research Service, Los Angeles

All Listed Sponsors
lead

University of California, Los Angeles

OTHER